A knowledge base article about How to change the default profile for your vsys provided by the UC Berkeley IT Service Hub - Knowledge Portal
For many campus firewall administrators, the Panorama “Security Profiles” and “Security Profiles Groups” created by the Information Security Office (ISO) should represent an acceptable balance between security and functionality and should work for most of their needs. These shared profiles can be identified by their name starting with “ucbsec-” and by their location in the Global Device Group. Further, the recommended settings have been grouped together into a default Profile group that will be assigned to new rules when they are created. If it is necessary for the majority of rules to get a profile group that is different from the default profile group then the following steps should be taken:
Below are the steps to modify the default profile group with a custom File Blocking profile. For information on creating a custom profile see the instructions at https://ucb.service-now.com/kb_view.do?sysparm_article=KBT0012686
Once this has been done, the default Profile Group will have the new profile associated with it.
PLEASE NOTE: This change will not only be in place for any new rules created, but will also affect any rules that were already created and had the default “Security Profile Group” assigned.